Constants reference
Every number the tools use, and where it came from.
This is the same dataset the calculators read from, not a copy that can drift out of sync. Each entry carries its source, the body that issued it, and whether it has been traced to a primary reference. Where a value has not yet been traced, that is shown honestly rather than presented as sourced. Link directly to any entry with its anchor.
Cite this page
ScienceExperts.ai (2026). Toxicology Suite constants reference, engine v0.3.0, last verified 2026-09-04. https://www.scienceexperts.ai/constants. Retrieved 2026-09-08.
Every entry below is directly citable at its own anchor.
Km divisors: animal-to-human conversion
FDA Guidance for Industry (CDER, July 2005), "Estimating the Maximum Safe Starting Dose in Initial Clinical Trials for Therapeutics in Adult Healthy Volunteers," Table 1. (FDA / CDER, 2005-07)
| Constant | Value | Status | Copy link |
|---|---|---|---|
Mouse Km divisor Animal-to-human body surface area conversion divisor (HED = NOAEL ÷ Km). | 12.3 | Sourced | |
Hamster Km divisor Animal-to-human body surface area conversion divisor (HED = NOAEL ÷ Km). | 7.4 | Sourced | |
Rat Km divisor Animal-to-human body surface area conversion divisor (HED = NOAEL ÷ Km). | 6.2 | Sourced | |
Ferret Km divisor Animal-to-human body surface area conversion divisor (HED = NOAEL ÷ Km). | 5.3 | Sourced | |
Guinea pig Km divisor Animal-to-human body surface area conversion divisor (HED = NOAEL ÷ Km). | 4.6 | Sourced | |
Rabbit Km divisor Animal-to-human body surface area conversion divisor (HED = NOAEL ÷ Km). | 3.1 | Sourced | |
Dog Km divisor Animal-to-human body surface area conversion divisor (HED = NOAEL ÷ Km). | 1.8 | Sourced | |
Monkey Km divisor Animal-to-human body surface area conversion divisor (HED = NOAEL ÷ Km). | 3.1 | Sourced | |
Marmoset Km divisor Animal-to-human body surface area conversion divisor (HED = NOAEL ÷ Km). | 6.2 | Sourced | |
Micropig Km divisor Animal-to-human body surface area conversion divisor (HED = NOAEL ÷ Km). | 1.4 | Sourced | |
Minipig Km divisor Animal-to-human body surface area conversion divisor (HED = NOAEL ÷ Km). | 1.1 | Sourced | |
Baboon Km divisor Animal-to-human body surface area conversion divisor (HED = NOAEL ÷ Km). | 1.8 | Sourced |
Reference body weight
| Constant | Value | Source | Status | Copy link |
|---|---|---|---|---|
US reference body weight FDA CDER 2005 default adult reference body weight. | 60kg | FDA Guidance for Industry (CDER, July 2005), "Estimating the Maximum Safe Starting Dose in Initial Clinical Trials for Therapeutics in Adult Healthy Volunteers," Table 1. (FDA / CDER, 2005-07) | Sourced | |
EU reference body weight 60 kg default retained for historical FDA/EMA back-calculation alignment; EMA 2017 does not codify a single reference BW. Editable per program. | 60kg | No single EMA-codified reference body weight exists; retained for historical FDA/EMA back-calculation alignment. (EMA (no single codified value), n/a) | Flagged |
Default safety factor
FDA Guidance for Industry (CDER, July 2005), "Estimating the Maximum Safe Starting Dose in Initial Clinical Trials for Therapeutics in Adult Healthy Volunteers," Table 1. Step 4. (FDA / CDER, 2005-07)
| Constant | Value | Status | Copy link |
|---|---|---|---|
Default safety factor Applied to the governing HED to derive the MRSD (MRSD = HED ÷ safety factor). | 10 | Sourced |
ICH S9 rule values
ICH S9, "Nonclinical Evaluation for Anticancer Pharmaceuticals." (ICH, unresolved)
| Constant | Value | Status | Copy link |
|---|---|---|---|
ICH S9 rodent starting-dose fraction Fraction of STD10 used as the oncology starting dose for rodent-only programs. | 10% | Flagged | |
ICH S9 non-rodent HNSTD divisor HNSTD is divided by this factor for non-rodent oncology programs. | 6 | Flagged |
Maximum dose volumes
Diehl et al., 2001, published industry dose-volume defaults. (Diehl et al. (2001), industry consensus, 2001)
| Constant | Value | Status | Copy link |
|---|---|---|---|
Mouse max dose volume, oral | 10mL/kg | Flagged | |
Mouse max dose volume, intravenous (bolus) | 5mL/kg | Flagged | |
Mouse max dose volume, intravenous (slow infusion) | 25mL/kg | Flagged | |
Mouse max dose volume, intraperitoneal | 20mL/kg | Flagged | |
Mouse max dose volume, subcutaneous | 10mL/kg | Flagged | |
Rat max dose volume, oral | 10mL/kg | Flagged | |
Rat max dose volume, intravenous (bolus) | 5mL/kg | Flagged | |
Rat max dose volume, intravenous (slow infusion) | 20mL/kg | Flagged | |
Rat max dose volume, intraperitoneal | 10mL/kg | Flagged | |
Rat max dose volume, subcutaneous | 5mL/kg | Flagged | |
Dog max dose volume, oral | 5mL/kg | Flagged | |
Dog max dose volume, intravenous (bolus) | 2.5mL/kg | Flagged | |
Dog max dose volume, intravenous (slow infusion) | 5mL/kg | Flagged | |
Dog max dose volume, subcutaneous | 1mL/kg | Flagged |
MABEL defaults
EMA guideline EMEA/CHMP/SWP/28367/07 Rev. 1 (July 2017) — the guidance the MABEL module is built against. (EMA, 2017-07)
| Constant | Value | Status | Copy link |
|---|---|---|---|
MABEL EC50/IC50 anchor fraction Default fraction of in vitro functional EC50/IC50 used to anchor the MABEL EC50-based mode. | 10% | Flagged | |
MABEL default volume of distribution Assumed volume of distribution multiplied against the EC50/IC50 anchor fraction in the MABEL EC50-based mode. | 0.07L/kg | Flagged |
Cell therapy defaults
| Constant | Value | Source | Status | Copy link |
|---|---|---|---|---|
Cell therapy default safety factor Applied to the nonclinical potency benchmark to derive the cell therapy starting dose. | 10 | No single codified cell-therapy safety-factor guidance is cited by the engine for this default. (Not regulatory — engine default, n/a) | Flagged | |
Cell therapy precedent-dose fraction Default fraction of the clinical-precedent dose used when the module's dose mode is precedent-based. | 10% | No single codified cell-therapy precedent-fraction guidance is cited by the engine for this default. (Not regulatory — engine default, n/a) | Flagged |